St John’s wort has a native geographical distribution including temperate and subtropical regions of North America, Europe, Turkey, Russia, India, China and Brazil.

It is widely known as an herbal medicine for treating depression. Large studies have shown that extracts of St John’s wort were superior to placebo in patients with major depression. St John’s wort had similar efficacy to standard antidepressants. The rate of side-effects was half that of newer SSRI antidepressants and one-fifth that of older tricyclic antidepressants. By having the same properties as antidepressants used to treat PE, St. John’s wort has been tested to be an invaluable option for the treatment of premature ejaculation. Its active ingredients hyperforin and hypericin modulate the serotonin pathway in the brain which is responsible for depression as well as premature ejaculation.

Hypericum Perforatum (St. John’s Wort) effects:

– Improvement of premature ejaculation

– Improvement of ejaculatory control

– Serotonin pathway modulator

– Antidepressant

– Strong antioxidant

Niacin (vitamin B3) is one of the 40 to 80 essential human nutrients, needed for healthy skin, hair, eyes, and liver. B vitamins also help the nervous system function properly, and niacin helps the body make various sex and stress-related hormones in the adrenal glands and other parts of the body. It has also been proven to be associated with a significant reduction in cardiovascular events and possible small but non-significant decreases in coronary and cardiovascular mortality.

Niacin effects:

– Positive cardiovascular properties

– Decreases LDL, increases HDL

– Antiinflammatory

– Neuroprotective

Ascorbic acid (AA) is one form of the potent vitamin C with strong antioxidant and cell protective properties. Its deficiency has been linked to behavioral changes, pure immune system and wound healing, as well as depressed mood. As a strong antioxidant, ascorbic acid helps to remove the free radicals and byproducts of pelvic contraction which affect the blood flow. By warding off harmful free radicals ascorbic acid prevents damage to the veins of the penis and helps to improve premature ejaculation over time.

Ascorbic Acid effects:

– Antioxidant and cell protective

– Immune support

– Wound healing support

Tryptophan is an essential amino acid that cannot be synthesized by the organism and therefore must be part of its diet. Amino acids, including tryptophan, act as building blocks in protein biosynthesis. In addition, tryptophan functions as a biochemical precursor for serotonin, niacin, and auxin. Tryptophan has been shown to aid with better sleep, lower fatigue perception, increase durability, and improve depression and anxiety, including performance anxiety.

L-Tryptophan Effects:

– Essential amino acid

– Precursor for serotonin, niacin, and auxin

Improves sleep

– Decreases fatigue perception and increases durability

– Improves depression and anxiety, including performance anxiety

Grape seed extract has been shown to affect heart diseases such as hypertension, high levels of blood cholesterol, platelet aggregation or inflammation, and having strong antioxidant effects. It is a great source of vitamin E, flavonoids, linoleic acid, and phenolic OPCs, which have great antioxidant properties.

Grape Seed Extract effects:

– Great Antioxidant

– Cardiovascular support

– Good source of Vitamin E

The organic compound citrulline is an α-amino acid. Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated in 1914. In recent studies, citrulline has been found to relax blood vessels improving blood circulation and erectile functioning. Furthermore, studies have shown that citrulline helps to reduce muscle fatigue, improves erection quality, reduce blood pressure, and be cardio protective.

L-citrulline effects:

– Improves blood circulation

– Improves erectile functioning

– Decreases muscle fatigue

– Reduces blood pressure

Cinnamon Aromaicum

As a warm and dry substance cinnamon was believed by doctors in ancient times to cure snakebites, freckles, the common cold, and kidney troubles, among other ailments. Taken orally it infuses the body with warmth and energy; it destroys all deep cold in the body. The Chinese Medicine has been using cinnamon for treatment of premature ejaculation for many centuries. Furthermore, cinnamon has been suggested in multiple studies to improve glycemic control and improve blood glucose levels. In addition, cinnamon scent has been shown to be the strongest aphrodisiac scent (between other herbal scents) stimulating men the most.

Cinnamon effects:

– Improves premature ejaculation

– Strong aphrodisiac

– Improves circulation

– Antioxidant

– Glycemic control

– Lipid control

– Protective for male reproductive system

– Antiinflammatory

– Antihistamine properties